Endocrine Abstracts

Severe hypothyroidism is a rare cause of precocious puberty, because long-standing primary hypothyroidism traditionally leads to both pubertal and growth delay. We report a case of a 4.7 year old girl presented with abdominal/pelvic pain and vaginal bleeding since 1 week. The child was diagnosed as a case with a right ovarian mass and was planned for surgery. She was born at term pregnancy without complication. Physical examination revealed typical features of hypothyroidism. ...

Introduction: Graves’ hyperthyroidism is an autoimmune disease sustained by auto antibodies binding to and activating the TSH receptor located on the thyroid follicular cell. The diagnosis of Graves’ hyperthyroidism is based upon clinical symptoms, signs and laboratory tests confirming the presence of thyrotoxicosis, positive thyroid peroxidase (TPO) and less commonly thyroglobulin (Tg) antibodies, and finally, positive serum TSH receptor antibodies (TRab). Recently ...